pI: 7.4079 |
Length (AA): 1176 |
MW (Da): 131609 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
175 | 850 | 5mpm (A) | 40 | 719 | 27.00 | 0 | 1 | 0.52413 | 1.42 |
252 | 388 | 2hc8 (A) | 220 | 321 | 34.00 | 0 | 1 | 0.225097 | -0.14 |
778 | 850 | 4bbj (A) | 574 | 641 | 38.00 | 0.00049 | 0.13 | 0.364375 | 0.12 |
804 | 893 | 4umw (A) | 600 | 690 | 20.00 | 0.00013 | 0.05 | 0.262531 | -0.31 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127785)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G23630 | putative cation-transporting ATPase |
Babesia bovis | BBOV_IV002730 | cation transporting ATPase, putative |
Brugia malayi | Bm1_38660 | Probable cation-transporting ATPase C10C6.6 in chromosome IV |
Candida albicans | CaO19.7701 | potential membrane protein similar to S. cerevisiae SPF1 (YEL031W) ER membrane P-type ATPase involved in calcium ion homeostasis |
Candida albicans | CaO19.30 | potential membrane protein similar to S. cerevisiae SPF1 (YEL031W) ER membrane P-type ATPase involved in calcium ion homeostasis |
Caenorhabditis elegans | CELE_C10C6.6 | Protein CATP-8 |
Cryptosporidium parvum | cgd6_720 | unknown protein |
Dictyostelium discoideum | DDB_G0293004 | hypothetical protein |
Drosophila melanogaster | Dmel_CG6230 | CG6230 gene product from transcript CG6230-RA |
Echinococcus granulosus | EgrG_000892300 | cation transporting ATPase 13A1 |
Entamoeba histolytica | EHI_065670 | cation-transporting P-typeATPase, putative |
Echinococcus multilocularis | EmuJ_000892300 | cation transporting ATPase 13A1 |
Giardia lamblia | GL50803_92246 | Cation-transporting ATPase 2, putative |
Homo sapiens | ENSG00000105726 | ATPase type 13A1 |
Leishmania braziliensis | LbrM.07.1110 | cation-transporting ATPase, putative |
Leishmania donovani | LdBPK_071210.1 | cation-transporting ATPase, putative |
Leishmania infantum | LinJ.07.1210 | cation-transporting ATPase, putative |
Leishmania major | LmjF.07.1050 | cation-transporting ATPase, putative |
Leishmania mexicana | LmxM.07.1050 | cation-transporting ATPase, putative |
Loa Loa (eye worm) | LOAG_07782 | hypothetical protein |
Mus musculus | ENSMUSG00000031862 | ATPase type 13A1 |
Neospora caninum | NCLIV_011090 | cation-transporting ATPase, putative |
Oryza sativa | 4338738 | Os05g0402800 |
Oryza sativa | 9271115 | Os05g0402850 |
Plasmodium berghei | PBANKA_0211900 | cation transporting ATPase, putative |
Plasmodium falciparum | PF3D7_0727800 | cation transporting ATPase, putative |
Plasmodium knowlesi | PKNH_0212400 | cation transporting ATPase, putative |
Plasmodium vivax | PVX_081695 | cation transporting ATPase, putative |
Plasmodium yoelii | PY01447 | Drosophila melanogaster BcDNA.GH06032 |
Saccharomyces cerevisiae | YEL031W | ion-transporting P-type ATPase SPF1 |
Schistosoma japonicum | Sjp_0314450 | Probable cation-transporting ATPase 13A1, putative |
Schistosoma japonicum | Sjp_0090140 | ko:K01552 ATP13A1, ATP13A; ATPase type 13A1 [EC:3.6.3.-], putative |
Schistosoma japonicum | Sjp_0048540 | Probable cation-transporting ATPase C10C6.6, putative |
Schistosoma mansoni | Smp_164540 | cation-transporting atpase 13a1 (G-box binding protein) |
Schmidtea mediterranea | mk4.003961.03 | Probable cation-transporting ATPase |
Schmidtea mediterranea | mk4.003961.00 | Probable cation-transporting ATPase |
Schmidtea mediterranea | mk4.003961.02 | |
Schmidtea mediterranea | mk4.003961.07 | |
Schmidtea mediterranea | mk4.017977.00 | |
Trypanosoma brucei gambiense | Tbg972.8.250 | cation-transporting ATPase, putative |
Trypanosoma brucei | Tb927.8.650 | cation-transporting ATPase, putative |
Trypanosoma congolense | TcIL3000_8_130 | cation-transporting ATPase, putative |
Trypanosoma cruzi | TcCLB.509611.80 | cation-transporting ATPase, putative |
Toxoplasma gondii | TGME49_318460 | P-type ATPase of unknown pump specificity (type V) protein |
Theileria parva | TP03_0375 | integral membrane protein, putative |
Trichomonas vaginalis | TVAG_173640 | cation-transporting ATPase, putative |
Trichomonas vaginalis | TVAG_182210 | cation-transporting ATPase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.650 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.650 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.650 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.650 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0211900 | Plasmodium berghei | Essential | plasmo |
TGME49_318460 | Toxoplasma gondii | Essentiality uncertain | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.